phytochemicals Phytochemicals

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Wound healing properties of seas-buckthorn.

A study conducted by Ianev and co-workers demonstrated that sea buckthorn extract stimulated the healing of wounds in rats. When the wound were treated with a gel containing the extract the granulation tissue differentiation and the epithelization was faster and the epithelization was also more intensive. They believe that the stimulating effect on the healing process was caused by the rich content of vitamins and microelements in the sea buckthorn extract [1]. Kumar, a researcher from the Defence Institute of Physiology and Allied Sciences ,India, believes that the flavones are responsible for the wound healing activity of sea buckthorn.

Topical administration of sea buckthorn flavone stimulated wound healing as indicated by improved rate of wound contraction, decreased epithelialization time and increase in hydroxyproline (major component of the protein collagen) and hexosamine (indicator of wound healing) content. Flavone treatment also resulted in a decrease in lipid peroxide levels [2]. In a previous study Kumar and co-workers found that a sea buckthorn leaf extract promoted wound healing. Topocal application of the extract significantly improved wound healing: the content of hydroxyproline was increased and the size of the wound area was reduced [3].

Sea buckthorn oil also seems improve healing of burn wounds. This was the conclusion of a Chinese study involving 151 burned patients. The doctors applied sea buckthorn oil dressing and found that the oil relieved the pain and alleviated swelling and effusion of the wounds [4].

[1] Ianev E, Radev S, Balutsov M, Klouchek E, Popov A. " The effect of an extract of sea buckthorn (Hippophae rhamnoides L.) on the healing of experimental skin wounds in rats " Khirurgiia (Sofiia). 1995;48(3):30-3.
[2] Gupta A, Kumar R, Pal K, Singh V, Banerjee PK, Sawhney RC. " Influence of sea buckthorn (Hippophae rhamnoides L.) flavone on dermal wound healing in rats." Mol Cell Biochem. 2006 Oct;290(1-2):193-8.
[3] Gupta A, Kumar R, Pal K, Banerjee PK, Sawhney RC." A preclinical study of the effects of seabuckthorn (Hippophae rhamnoides L.) leaf extract on cutaneous wound healing in albino rats." Int J Low Extrem Wounds. 2005 Jun;4(2):88-92.
[4] Wang ZY, Luo XL, He CP. "Management of burn wounds with Hippophae rhamnoides oil " Nan Fang Yi Ke Da Xue Xue Bao. 2006 Jan;26(1):124-5.

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