phytochemicals Phytochemicals

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Anti-helicobacter activity of broccoli and broccoli sprouts.

A group of scientists led by Galan at the William Beaumont Hospital, Royal Oak, Michigan, were the first to do a preliminary study on the effect of broccoli sprout consumption on small group of patients infected with Helicobacter pylori [1]. They found that seven of nine patients became stool antigen negative after a week treatment with broccoli sprouts, and six of them remained negative at day 35. Of the five patients who provided information on symptoms, two reported improvement, one no change and one reported worsening. They concluded that more studies are needed to determine the optimal dose of broccoli sprouts and to determine whether medicines that suppress stomach acid production or antibiotics might improve the effectiveness.

A study by The Johns Hopkins University School of Medicine, Baltimore, investigate the inhibitory action of sulforaphane against Helicobacter pylori and found that sulforaphane had significantly more bacteriostatic activity against Helicobacter pylori than other tested phytochemicals [2]. The scientists concluded that the sulforaphane could eradicate resistant strains of Helicobacter pylori.

Moon and co-workers at University of California found that broccoli is an excellent food source for antibacterial substances. They prepared extracts from fresh broccoli using different solvents [3]. They found that most extracts showed inhibition zones for Helicobacter pylori. They identified several sulforaphane-related compounds such as sulforaphane, 5-methylsulfinylpentylnitrile and 4-methylsulfinylbutylnitrile.

A study conducted at the Tokyo University of Science showed that daily intake of sulforaphane-rich broccoli sprouts for 2 months reduces Helicobacter pylori colonization in mice and improves the side effects of infection in infected mice and in humans. Broccoli sprouts also seemed to improve chemoprotection of the gastric mucosa against Helicobacter pylori-induced oxidative stress.

[1] Oral broccoli sprouts for the treatment of Helicobacter pylori infection: a preliminary report. Dig Dis Sci. 2004 Aug;49(7-8):1088-90.
[2] Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo-a-pyrene-induced stomach tumors. PNAS,May 28, 2002;99(11):7610-7615.
[3] Analysis and anti-Helicobacter activity of sulforaphane and related compounds present in broccoli ( Brassica oleracea L.) sprouts. J Agric Food Chem. 2010 Jun 9;58(11):6672-7.
[4] Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. Cancer Prev Res (Phila). 2009 Apr;2(4):353-60.

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