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Myricetin may help o improve heart health.

Dietary flavonoids have been inversely associated with the incidence of coronary artery disease. Researchers from the Chia-Nan University of Pharmacy and Science, Taiwan, reported that myricetin, and other flavonoids, prevented LDL from oxidation and reduced the uptake of oxidized LDL by macrophages [1]. Myricetin inhibited Cu(2+)-mediated LDL oxidation and reduced the expression of the membrane protein CD36, which can bind many ligands, including oxidized low density lipoprotein. The study concluded that flavonols, such as myricetin, may play a role in ameliorating atherosclerosis.

A study conducted by SM Rankin and co-workers of King's College, London, found that myricetin at high concentrations modified LDL by a non-oxidative mechanism into a form that was easier absorbed by macrophages. They came to this conclusion after determining the absorption labeled LDL, treated with up to 1000 microM myricetin, by mouse peritoneal macrophages. Sometimes flavonoids can as pro-oxidants but myricetin did oxidize LDL and did not deplete the endogenous antioxidant alpha-tocopherol in the LDL.

[1] Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages. Biochim Biophys Acta. 2008 Oct;1781(10):601-9.
[2] The modification of low density lipoprotein by the flavonoids myricetin and gossypetin. Biochem Pharmacol. 1993 Jan 7;45(1):67-75.

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