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Sea buckthorn and healing effect on gastric ulcers


Extracts and oil form sea buckthorn have traditionally been used to treat mucosa problems. One Chinese study with rats confirmed that sea buckthorn oil extracted from the seed and pulp have protective against experimental gastric ulcers. They came to this conclusion after they found that the administration of rats with both types of oil during two weeks significantly reduced the formation of ulcers induced by oil-immersion or reserpine treatment. Also the healing process of acetic acid induced ulcers was stimulated [1].



Procyanidins extracted from the bark of sea buckthorn showed wound healing effect on gastric ulcers induced by acetic acid. The researchers of Huazhong Agricultural University (China) induced gastric ulcers in rats by injection of acetic acid in subserosa of the stomach. After a treatment of up to 2 weeks various parameters were determined: ulcer index, plasma level of epidermal growth factor, expression of epidermal growth factor receptor and proliferating cell nuclear antigen. They found that the extract from sea buckthorn procyanidins dose dependently reduced the size of the ulcers. The ulcer index was reduced by the extract, whereas both the plasma level of epidermal growth factor, expression of epidermal growth factor receptor and proliferating cell nuclear antigen were increased [2].

[1] Xing J, Yang B, Dong Y, Wang B, Wang J, Kallio HP." Effects of sea buckthorn (HippophaŽ rhamnoides L.) seed and pulp oils on experimental models of gastric ulcer in rats." 1: Fitoterapia. 2002 Dec;73(7-8):644-50.
[2] Xu X, Xie B, Pan S, Liu L, Wang Y, Chen C. "Effects of sea buckthorn procyanidins on healing of acetic acid-induced lesions in the rat stomach." Asia Pac J Clin Nutr. 2007;16 Suppl 1:234-8





 
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