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Kaempferol

Kaempferol

MW: 286.24
Formula: C15H10O6

What is Kaempferol?

Pure kaempferol is a yellow coloured powder. Amphoral is one of the most important and most widespread flavonoids (containing the typical C6-C3-C6 structure).

Distribution

Kaempferol is a flavonoid present in various natural sources including apples, onions, leeks, citrus fruits, grapes, red wines, gingko biloba, St. John's wort.

Health Benefits of Kaempferol

Keampferol is a strong antioxidant and helps to prevent oxidative damage of our cells, lipids and DNA. Kaempferol seems to prevent arteriosclerosis by inhibiting the oxidation of low density lipoprotein and the formation of platelets in the blood. Studies have also confirmed that kaempferol acts as a chemopreventive agent, which means that it inhibits the formation of cancer cells.

An in vitro study by Jan Kowalski et al (Pharmacological Reports, 2005) showed that kaempferol inhibits monocyte chemoattractant protein (MCP-1). MCP-1 plays a role in the initial steps of atherosclerotic plaque formation.

The flavonoids kaempferol and quercetin seems to act synergistically in reducing cell proliferation of cancer cells, meaning that the combined treatments with quercetin and kaempferol are more effective than the additive effects of each flavonoid. This was a conclusion from a study by ML Ackland et al (In Vivo, Feb 2005) titled "Synergistic antiproliferative action of the flavonols quercitin and kaempferol in cultured human cancer cell lines"".

A study "Inhibition of P-glycoprotein function and expression by kaempferol and quercetin" by the Chiang Mai University, Thailand, found that kaempferol can help to fight cancer because it reduces the resistance of cancer cells to anti-cancer drugs such as vinbalstine and paclitaxel.

Synonyms

Campherol, indigo yellow, nimbecetin, 3,4',5,7-Tetrahydroxyflavone



 
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