Some studies have focused on the ability of isorhamnetin to attenuate diabetes complications such as diabetic cataract, lipid peroxidation and high blood glucose levels.
Lee YS an co-workers of the Seokwon Life Science Research Institute, Korea, tested the effect of different extracts from jointed glasswort (Salicornia herbacea), on streptozotocin-induced diabetic rats and on the activity of rat lens aldose reductases [1]. Their in-vitro test showed that the extract which contained isorhamnetin-3-O-beta-D-glucoside showed a strong inhibition of rat lens aldose reductases. When the same extract was administered orally to streptozotocin-induced diabetic rats, serum glucose level was reduced but also the sorbitol accumulation in the lenses, red blood cells and sciatic nerves dropped. The researchers concluded that the isorhamnetin-rich glasswort extract should be further investigated a potential drug for candidate for the prevention and treatment of diabetes and its complications.
A Japanese study from the Toyama Medical and Pharmaceutical University also indicated that isorhamnetin could be beneficial for diabetes patients. A team lead by Yokozawa T investigated the effect of isorhamnetin diglucoside on oxidative stress induced by diabetes mellitus. They found that oral administration of isorhamnetin diglucoside to rats with streptozotocin-induced diabetes significantly reduced serum levels of glucose, hydroxymethyl furfural and thiobarbituric acid-reactive substance levels of serum, and liver and kidney mitochondria. Mainly the aglycone form, isorhamnetin, was responsible for this action.
[1] Lee YS, Lee S, Lee HS, Kim BK, Ohuchi K, Shin KH. "Inhibitory effects of isorhamnetin-3-O-beta-D-glucoside from Salicornia herbacea on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues." Biological & Pharmaceutical Bulletin. 2005 May;28(5):916-8.
[2] Yokozawa T, Kim HY, Cho EJ, Choi JS, Chung HY. "Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes." " Journal of Agricultural and Food Chemistry. 2002 Sep 11;50(19):5490-5.
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