Inhibition of tamoxifen's therapeutic benefit by tangeretin in mammary cancer.
European Journal of Cancer. 2000 September;36 Suppl 4:S73
Previous in-vitro studies indicate that the flavonoids tangeretin (found in citrus fruits and some menopausal medications) suppresses tumour growth and invasion of human breast cancer cells. The oral intake of tangeretin by rats reduces the tumor-suppressing effects of tamoxifen because it reduces the number of natural killer cells, which play a major role in the rejection of tumors.
Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.
Journal of the National Cancer Institute. 1999 February 17;91(4):354-9
In vitro studies have shown that both the drug tamoxifen and the natural citrus flavonoid tangeretin inhibit the growth and invasive properties of human mammary cancer cells. The aim of this study was to see if tamoxifen and tangeretin showed similar effects in vivo. Female mice were injected with carcinoma cells and orally administered with either tamoxifen, tangeretin, tamoxifen plus tangeretin or a placebo. The researchers found that tangeretin failed to inhibit tumor growth and neutralized the anti-tumor activity of tamoxifen. The cytolytic effect of tangeretin on natural killer cells may explain its neutralizing effect on the activity of tamoxifen. The researchers warned against the consumption of tangeretin, for example through supplements, during tamoxifen treatment of mammary cancer.
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