Protective effect of steroidal saponins from rhizome of Anemarrhena asphodeloides on ovariectomy-induced bone loss in rats.
Acta Pharmacologica Sinica. 2006 June;27(6):728-34
The aim of this study was to determine the protective role on bone loss of steroidal saponins from Anemarrhena asphodeloides, a Chinese herb, on ovariectomized rats. The rats were treated with nylestriol (a synthetic hormone with estrogenic activities) that is metabolized into ethynyl estriol and estriol) or steroidal saponins during 12 weeks. The researchers found that the steroidal saponins increased the levels of alkaline phosphatase and decreased level of osteocalcin. Body weight was not influenced by the treatment. They found that the atrophy of the uterus and decrease of bone mineral density were decreased. Saponins also resulted in increased bone formation. The study concluded that steroidal saponins of Anemarrhena asphodeloides prevented ovariectomized induced bone loss in rats.
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