Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship.
Chemical & Pharmaceutical Bulletin. 2005 November;53(11):1451-4
The aim of this study was to determine the antitumor properties of saponins from the root of Korean pasque flower (Pulsatilla koreana). The researchers measured the in-vitro cytotoxic activity against cultured human solid cancer cells and the in-vivo antitumor activity in mice bearing lung carcinoma. The saponins with a free acidic group at C-28 of aglycon showed moderate to considerable in-vitro cytotoxic activity. In the in-vivo test hederagenin saponins showed stronger antitumor effect than the taxol and doxorubicin saponins. The precense of a hederagenin aglycones and a special sugar sequence at C-3 are essential factors for the antitumor activity of saponins.
Protective effect of Astragalus corniculatus saponins against myeloid graffi tumor in hamsters.
Phytother Research. 2004 March;18(3):255-7
This study investigated the antitumor effect of a saponin rich extract from Astragalus corniculatus Bieb, a garden plant originating from Eastern European, against myeloid Graffi tumors in hamsters. The researchers found that an injection of extract in the peritoneal cavity decreased tumor transplantability, inhibited tumor growth in the early stages of tumor progression, increased survival time and reduced mortality. The study concluded that the saponin extract of Astragalus corniculatus should be further investigated as a antitumor treatment of myeloid Graffi tumour.
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