Central nervous system protection by resveratrol in streptozotocin-induced diabetic rats.
Journal of Clinical Neuroscience. 2007 March;14(3):256-60
The aim of this study was to determine the protective role of resveratrol against high blood glucose levels induced in rats by the drug streptozotocin. This drug is used in medical research to produce an animal model for type 1 diabetes. The researchers found that the administration of resveratrol offered protective action in the brain and spinal cords because it reduced lipid peroxidation and increased glutathione levels. The study concluded that resveratrol is a potential neuroprotective agent against diabetic oxidative damage.
Effect of resveratrol, a polyphenolic phytoalexin, on thermal hyperalgesia in a mouse model of diabetic neuropathic pain.
Fundamental & Clinical Pharmacology. 2007 February;21(1):89-94
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
Diabetic neuropathic pain is a symptom associated with diabetes mellitus. This condition is the result of injury to small blood vessels that supply the nerves. Diabetic neuropathic pain is very difficult to treat. The aim of this in vivo study was to determine the effect of resveratrol on diabetic neuropathic pain. The researchers also measured the effect of resveratrol on the serum level of tumour necrosis factor-alpha and whole brain nitric oxide release. The tests ware carried out mice treated with streptozotin to produce an animal model for Type 1 diabetes. The researchers found that an injection with resveratrol significantly and dosedependently attenuated thermal hyperalgesia, decreased the serum level of tumour necrosis factor-alpha and whole brain nitric oxide release. They concluded that resveratrol holds a potential in attenuating diabetic neuropathic pain.
Resveratrol inhibits insulin secretion from rat pancreatic islets.
European Journal of Pharmacology. 2006 December 15;552(1-3):176-81
The phytochemical resveratrol is known to have cardioprotective, anticancer and antioxidant activity but resent research also indicate that resveratrol may help to elevate diabetic complications. The aim of this study to determine the effect of resveratrol on insulin secretion from incubated pancreatic islets. The researchers found that resveratrol restricted the release of insulin after being exposed to glucose. They concluded that resveratrol exerts reversible inhibitory effect on insulin secretion from incubated pancreatic islets.
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