Resveratrol alleviates bleomycin-induced lung injury in rats.
Pulmonary Pharmacology and Therapeutics. 2006 September 3
Bleomycin, a chemotherapeutic agent, can cause pulmonary fibrosis and impaired lung function. Bleomycin causes DNA strand to break and results in lipid peroxidation and oxidation of other cellular molecules. The objective of this study was to investigate the protective effects of resveratrol on pulmonary fibrosis induced by bleomycin. The study was carried out on rats received a placebo or resveratrol for 14 days. Bleomycin caused several biochemical changes: a significant decrease in lung glutathione levels, an increase in malondialdehyde levels, increased activity of myeloperoxidase and increased level of collagen contents of the lung tissue. These changes were reversed when the rats were treated with the antioxidant resveratrol. The study concluded that resveratrol can be used as a supplement to alleviate the side effects of bleomycin treatment.
Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver.
Life Science. 2006 December 15
This study looked at the protective effects of resveratrol on oxidative damage of the liver cells caused by chronic alcoholic consumption. The study was carried out on rats which received daily 1 g ethanol per kg bodyweight. This quantity corresponds to an adult drinking daily 1 bottle of wine. Chronic intake of ethanol results in hepatotoxicity, resulting in increased levels of hepatic marker enzymes and the development of symptoms such as necrosis, fibrosis and inflammation. The intake of alcohol also increase the production of malonic dialdehyde indicating the peroxidation of lipids. The researchers found that the rats which were supplemented with resveratrol showed lower levels of lipid peroxidation and increased levels of antioxidant enzymes. They concluded that resveratrol could inhibit the oxidative damage caused by chronic ethanol intake.
Resveratrol can only partially attenuate ethanol-induced oxidative stress in embryonic chick brains.
Nutritional Neuroscience. 2006 June-August;9(3-4):121-9
This study investigated the potential protective effect of resveratrol on the damage caused by ethanol on the development of embryonic chick brains. Previous in-vitro studies demonstrated that resveratrol reduced ethanol induced damage. The researchers found that resveratrol attenuated reduction of the levels of unsaturated long-chain membrane fatty acids, but had no effect on elevated brain lipid hydroperoxides levels and increased brain caspase-3 activities.
Neuroprotective Effects of Resveratrol against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress in Rats.
Pharmacology. 2007;79(1):17-26. 2006, November 28
Alzheimer's disease is a type of dementia characterized by progressive cognitive deterioration. The administration of the drug colchicines also result in the loss of cognitive function that is associated with production of free radicals. This study investigated the protective effect of resveratrol in rats treated with colchicines. The researchers found that treatment with resveratrol significantly improved the cognitive function and reduced oxidative stress markers such as malondialdehyde and nitrite levels. They concluded that resveratrol has a neuroprotective role against cognitive impairment and associated oxidative stress induced by the drug colchicines.
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