Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells.
Journal of Biological Chemistry. 2007 February;388(2):207-19
Previous studies have shown that phytochemical resveratrol has antioxidant properties and influences the cellular redox reactions in eukaryotic cells. The researchers investigated the effects of resveratrol on the transcription of genes and activity of enzymes involved with the redox metabolism and cell cycle regulation in lung cancer cells. They found that resveratrol significantly increased the transcription of glutathione peroxidase resulting in lower glutathione levels. Glutathione also increased the transcription of many genes involved in the cell cycle, differentiation and apoptosis. The researchers concluded that resveratrol increased the expression of genes responsible for cell survival, differentiation, proliferation inhibition and apoptosis. Resveratrol may therefore have a chemopreventive and anticancer effect.
Effect of resveratrol and mixtures of resveratrol and mitomycin C on cancer cells under irradiation.
Anticancer Research. 2006 November-December;26(6B):4403-8
This study investigated the antitumor and radiation protective effects of resveratrol in combination with mitomycin-C, an antibiotic that is also used as chemotherapeutic agent because of its antitumour activity. The in-vitro tests were carried out on human breast cancer cells in aerated and anaerobic media. In the aerated media resveratrol showed anti-tumor and antioxidant activities, which were enhanced by mitomycin-C. Under anaerobic conditions, resveratrol acted as a radiation-protecting agent and at high concentration it stopped cell growth. The study concluded that resveratrol has both radiation protective and anticancer activity. Resveratrol acts by ejection of electrons and by reacting on primary radicals, such as hydroxyl radical.
Resveratrol Inhibits Pancreatic Cancer Cell Proliferation through Transcriptional Induction of Macrophage Inhibitory Cytokine-1.
Journal of Surgical Research. 2007 January 24
Resveratrol is a phytochemical found in many mainly in red grape skins, mulberries and some nuts. Previous studies have shown that resveratrol has potential antitumorigenic and anti-inflammatory activities. It is known that macrophages produce a cytokine (MIC-1) which has antitumorigenic activity. The aim of this in-vitro study was to determine the effect resveratrol on the activity of MIC-1 and the regulation the growth of lines human pancreatic cancer cells. The researchers found that resveratrol upregulated the expression of the MIC-1 gene. When the cells were first treated with a transcriptional inhibitor the effect of resveratrol was reduced, confirming that resveratrol works expression of genes. The study concluded that resveratrol increases MIC-1 gene expression in pancreatic cancer cells.
Resveratrol inhibits proliferation, induces apoptosis and overcomes chemoresistance through downregulation of STAT3 and nuclear factor-{kappa}B-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.
Blood, 15 March 2007, Vol. 109, No. 6, pp. 2293-2302
This study investigated the effect of resveratrol, a phytochemical found in red grapes, red berries and peanuts on the growth of human multiple myeloma cells. Multiple myeloma is cancer of immune system cells in bone marrow. Bhardwaj and his colleagues found that resveratrol inhibited the proliferation of human multiple myeloma cell lines. Resveratrol also increased the apoptotic affect of bortezomib and thalidomide. They concluded that resveratrol may have a potential in the treatment of multiple myeloma cancer.
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells.
Molecular Cancer. 2006 October 17;5:45
Endometrial cancers (cancer of the lining of the uterus) are the most common gynecologic cancers in the Western world. Studies have shown that resveratrol, an anti-oxidant found in high quantities in red wine, has anticancer activity and acts by inhibiting the proliferation and inducing apoptosis of cancer cells. The aim of this study was to investigate the antiproliferative and apoptotic activity of resveratrol in six different endometrial cancer cell lines. The researchers found that resveratrol caused apoptosis apoptosis in five out of six uterine cancer cell lines and decreased cell proliferation. They found that resveratrol acts by regulating the cyclooxygenase expression.
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