Proanthocyanidin from grape seeds enhances anti-tumor effect of doxorubicin both in vitro and in vivo.
Pharmazie. 2005 July;60(7):533-8
The aim of this study was to investigate the synergistic effect of proanthocyanidin on the anticancer activity of the drug doxorubicin. The study involved an in-vitro test with cultured cancer cells (leukemia, long cancer and nasopharyngeal cancer) and in in-vivo test where cancer cells (liver cancer and sarcoma cells) were implanted in mice. The researchers found that proanthocyanidin inhibited proliferation of the cultured cancer cells in a dose-dependent manner. The combination of proanthocyanidin and doxorubicin resulted in a synergistically inhibition. The growth of the transplanted cancer cells was also inhibited when the mice received proanthocyanidin and doxorubicin. The study concluded that proanthocyanidin enhances the anticancer effect of doxorubicin and that this effect was caused by increasing the intracellular levels of doxorubicin, calcium and magnesium.
Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism.
International Immunopharmacology. 2005 July;5(7-8):1247-57
This study investigated the anti-tumor activities of proanthocyanidin from grape seeds and doxorubicin, a DNA-interacting drug widely used in chemotherapy. The test was carried out in-vitro with lymphoma cancer cells and in vivo with mice. Both the proanthocyanidin and doxorubicin inhibited the proliferation of the lymphoma cancer cell in a dose-dependant manner. The combination of proanthocyanidins and doxorubicin strongly inhibited cell proliferation. In mouse with implanted tumors the administration of proanthocyanidin significantly inhibited the growth of the tumor? The combination of doxorubicin and proanthocyanidin worked synergistically. The study concluded that procyanidin has anti-tumor activity and increases the anti-tumor activity of doxorubicin.
Proanthocyanidin from grape seeds enhances doxorubicin-induced antitumor effect and reverses drug resistance in doxorubicin-resistant K562/DOX cells.
Canadian Journal of Physiology and Pharmacology. 2005 March;83(3):309-18
This study investigated the effect of proanthocyanidins on the antitumor activity of doxorubicin. Proanthocyanidins showed a significant inhibition of the proliferation of different cell cancer lines in a dose-dependant manner and synergistically improved the antitumor activity of doxorubicin. Proanthocyanidin also reverses resistance to doxorubicin in doxorubicin-resistant cells. In vivo experiments demonstrated that proanthocyanidins improved the inhibitory effect of doxorubicin on the growth of transplanted tumor sarcoma. The study concluded that proanthocyanidins enhance antitumor effect of doxorubicin and that several mechanisms may explain this effect.
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