Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of highly metastatic breast carcinoma cells.
Carcinogenesis. 2006 August;27(8):1682-91
Phytochemicals may offer protection against metastatic breast cancer. This study investigates the anticancer effect of grape seed proanthocyanidins on cultured breast cancer cells and on breast cancer cells implanted in mice. The researchers found that the grape seed proanthocyanidins significant dose-dependant inhibition of the proliferation and viability of the cultured breast cancer cells. The induction of apoptosis involved both caspase activation-dependent and activation-independent pathways. The in-vivo study with mice showed that the intake of grape seed proanthocyanidins significantly inhibited the growth of the implanted breast tumor cells. Also the metastasis of breast cancer cells to other organs was inhibited. The study concluded that grape seed proanthocyanidins may possess anticancer activity against breast cancer.
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