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Pomegranate and Cancer - Colon Cancer, Prostate Cancer |
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Prostate cancer prevention through pomegranate fruit.
Cell Cycle, 2006 February; 5(4):371-3
Prostate cancer is the second leading cause of cancer deaths in many Western countries. Because prostate cancer progresses very slowly it is an ideal subject for research. Pomegranate contains high levels of antioxidants and phytochemicals with anti-inflammatory properties. This study investigated the effect of a pomegranate extract inhibited cell growth and caused apoptosis of highly aggressive human prostate cancer cells. Consumption of pomegranate may retard prostate cancer progression and may prolong the survival of prostate cancer cells.
Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells.
Journal of Agricultural and Food Chemistry, 2006 February, 8;54(3):980-5
Phytochemicals from pomegranate may inhibit cancer cell proliferation and apoptosis. These phytochemicals act by modulating the cellular transcription factors and signaling proteins. Other studies showed that pomegranate juice and its ellagitannins inhibited proliferation and induced apoptosis of colon cancer cells. The researchers concluded that polyphenols in pomegranate can play an important role in the modulation of inflammatory cell signaling in colon cancer cells.
Anticancer activities of pomegranate extracts and genistein in human breast cancer cells.
Journal of Medicinal Food, 2005;8(4):469-75
Other studies showed that pomegranate extracts and genistein have anti-carcinogenic activity. For this study the scientists tested the potential anticancer effects of pomegranate extracts and genistein on the inhibition of cell proliferation and induction of apoptosis in human breast cancer cells. They found that pomegranate extracts and genistein had were cytotoxic to the cancer cells and they they inhibited their growth. The combined treatment of pomegranate extracts and genistein was more effective than the single treatments.
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