A novel property of an aqueous guaranį extract (Paullinia cupana): inhibition of platelet aggregation in vitro and in vivo.
Brazilian Journal of Medical and Biological Research. 1988;21(3):535-8
This study investigated the effect of a aqueous extracts of guarana on platelet aggregation. The researchers found that the extract inhibited the aggregation of human and rabbit platelets in vitro. The active phytochemicals were not identified but appeared to be different from salicylates, nicotinic acid or xanthines. The in vivo tests with rats, which were administered with the extract (intravenously or orally) also showed inhibition of platelet aggregation.
An aqueous extract of guaranį (Paullinia cupana) decreases platelet thromboxane synthesis.
Brazilian Journal of Medical and Biological Research. 1991;24(4):421-4
Previous studies by Bydlowski SP showed that an aqueous extract of guarana inhibits platelet aggregation in vivo and in vitro. This study also investigated the effect of this extract on thromboxane level. Thromboxane is a vasoconstrictor and a potent hypertensive agent which facilitates platelet aggregation. The researchers found that the guarana extract decreased thromboxane levels. This reduction could at least partly explain the beneficial effects of guarana extract on platelet aggregation.
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