Phytic Acid Modulates In Vitro IL-8 and IL-6 Release from Colonic Epithelial Cells Stimulated with LPS and IL-1beta.
Digestive Diseases Sciences. 2006 December 12
Phytic acid is present in wheat bran and legumes and is associated with fibres. The aim of this study was to determine the influence of phytic acid on the immunologic function of intestinal epithelial cells. The human colon cells were exposed to bacterial lipopolysaccharides, from tow strains of Desulfovibrio desulfuricans and one strain of Escherichia coli. The researchers found that phytic acid dose-dependently reduced interleukin-8 release of colonocytes stimulated with lipopolysaccharides and interleukin-1 beta. Phytic acid also increased constitutive interleukin-6 secretion and the response on lipopolysaccharides depended on the bacterial source. The study concluded that phytic acid may exert immunoregulatory effects in the intestine and may help to maintain the non-inflammatory state of the colonic during microbial infection.
Antiinflammatory and antiulcer activities of phytic acid in rats.
Indian Journal of Experimental Biology. 2004 February;42(2):179-85
The researchers determined the anti-inflammation activity of phytic acid on paw edema of rats, induced with the injection of carrageenan and on gastric tissue exposed to ibuprofen, ethanol and cold stress. They found that pretreatment with phytic acid protected the gastric mucosa from the adverse effects of ethanol. The study concluded that in an induced rat paw model phytic acid may protect the gastric tissue by its antioxidant and cytoprotective activity. The ability of phytic acid to inhibit the thermal denaturation of proteins may explains its anti-inflammation activity.
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