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Anticancer effects of phytic acid |
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Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.
Journal of Nutrition. 2003 November;133:3778S-3784S.
Phytic acid seems only to affect cancer cells and not normal cells. Phytic acid and inositol improves the effectiveness of chemotherapy. More studies are required to determine optimal dosage, effectiveness and safety of phytic acid.
The biochemical changes associated with phytic Acid on induced breast proliferative lesions in rats: preliminary findings.
Cancer Biology and Therapy. 2006 September;5(9):1129-33
Previous studies shown that phytic acid inhibits or prevents the growth of neoplasms. The aim of this study was to investigate if phytic acid has an effect on tumorigenesis by inducing apoptosis and inhibiting of oxidative stress. The in-vivo test was carried out on rats which were treated with the carcinogen dimethylbenz(a)anthracene (DMBA). The researchers found that the administration of phytic removed the benign proliferative breast changes. Phytic acid significantly decreased trichostatin A and nitric oxide levels and increased apoptosis. The study concluded that the administration of phytic acid reversed the proliferative effects of the carcinogen DMBA, and could have a protective effect.
Interactive suppression of aberrant crypt foci induced by azoxymethane in rat colon by phytic acid and green tea.
Carcinogenesis. 1997 October;18(10):2023-6
Epidemiological studies show a relation between diet and the incidence of colon cancer. Both phytic acid and phytochemicals in green tea seems to act as anticancer agents and have been linked wit reduced risk of cancer. The aim of this in vivo study with rats was to determine the possible synergistic effect of phytic acid and green tea on the inhibition of colonic preneoplastic lesions formations and the enzyme glutathione S-transferase. The rats were treated with the carcinogen azoxymethane and received different combinations of phytic acid and green tea. The researchers found that green tea alone had only marginal effect whereas phytic acid significantly reduced the incidence of aberrant crypt foci. The combination of phytic acid and green tea showed a significant and synergistic anticancer effect.
Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention.
Biochemical and Biophysical Research Communications. 2001 November 2;288(3):552-7
According to K Midorikawa and colleagues, phytic acid is one of the most promising cancer chemopreventive agents. The aim of this study was the determine the anticancer mechanism of phytic acid. They found that phytic acid inhibited the oxidative damage of hydrogen peroxide, but that phytic acid did not directly scavenge hydrogen peroxide. Phytic acid did not cause damage to DNA. They concluded that phytic acid acts as an antioxidant and anticancer agent by chelating metals.
Antitumor activity of phytic acid (inositol hexaphosphate) in murine transplanted and metastatic fibrosarcoma, a pilot study.
Cancer Letters. 1992 July 31;65(1):9-13
In vivo tests have shown that phytic acid exerts a antitumor effect on experimental colon cancer. The purpose of this study was to determine the antitumor activity of phytic acid on other experimental tumor models, such as murine fibrosarcoma. The researchers found that the intraperitoneal injection of mice with phytic acid reduced the growth of subcutaneously transplanted fibrosarcoma and prolonged survival. Phytic acid could have a potential use in the therapy of cancer.
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