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Induction of extracellular matrix synthesis in normal human fibroblasts by anthraquinone isolated from Morinda citrifolia (Noni) fruit.
Journal of Medicinal Food. 2005 Winter;8(4):552-5
Previous in vitro studies with cultured human dermal fibroblasts have shown that extract from noni increased production of collagen. The aim of this study was to identity the phytochemicals responsible for this action. The researchers succeeded in isolating the phytochemical 1,4-dihydroxy-2-methoxy-7-methylanthraquinone. This anthraquinone significantly increased production of procollagen and glycosaminoglycans and reduced expression of the collagenase. The study concluded that anthraquinone from Noni extract could be used as a possible anti-wrinkle agent.
Hepatotoxicity of NONI juice: report of two cases.
World Journal of Gastroenterology. 2005 August 14;11(30):4758-60
NoniI juice (Morinda citrifolia) is becoming more popular as a health ingredient in wellness drinks. Noni has been claimed to be beneficial for many diseases. But recently there were cases of liver intoxication. Therefore the toxicity of noni juice was reassessed. One patient had to undergo a liver transplantation and another patient recovered after stopping intake of noni juice. The first patient with previous toxic hepatitis associated with paracetamol developed hepatic failure after consuming nearly two liters of noni juice. The hepatotoxicity is probably linked to anthraquinones. Following this negative publicity, most noni juice producers recommend a daily intake of max 30 ml noni juice.
Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia (noni).
Angiogenesis. 2003;6(2):143-9
Noni juice has been used traditionally for its medicinal properties. The aim of this study was to investigate the effect of noni juice on the development of blood vessel. The study used a fibrin clot matrix model with human placental vein and human breast tumor explants. The researchers found that noni juice at concentrations of 5 percent effectively reduced blood vessel development and reduced the growth rate of new vessels.
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