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Cholesterol lowering properties of nobiletin |
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Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages.
Atherosclerosis. 2005 January;178(1):25-32
Citrus flavonoids are associated with a reduced risk of coronary heart disease because they reduce plasma cholesterol levels. In atherosclerotic lesions, macrophages that express scavenger receptors on their plasma membrane absorb oxidized LDL deposited in the blood vessel wall thereby becoming foam cells. These cells secrete inflammatory cytokines and accelerate the development of atherosclerosis. This study examined the antiatherogenic effect of phytochemicals on the modulation of macrophage metabolism of cultured macrophages. They were pre-treated with following flavonoids: naringenin, hesperetin, tangeretin and nobiletin. All flavonoids significantly reduced the metabolism of beta-VLDL, but only nobiletin inhibited acetylated LDL metabolism that was linked to the class A scavenger receptor. The study concluded that nobiletin reduces plasma cholesterol concentrations and may prevent atherosclerosis by inhibiting the formation macrophage foam cells.
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