Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant.
Biological and Pharmaceutical Bulletin. 2002 September;25(9):1137-41
This study is also about the phytochemicals in the hull of mangosteen (Garcinia mangostana), which has been used traditionally by the Thais medicinal purpose to treat allergy. The aim of this study was to determine the effect of extract from mangosteen hull on anti-inflammatory indicators such as histamine release and prostaglandin E2 production. The researchers found that a 40 percent ethanol extract of mangosteen hull inhibited IgE-mediated histamine release. The inhibition was higher than that of Rubus suavissimus, which is traditionally used as anti-allergy medicine in Japan. All tested mangosteen extracts inhibited prostaglandin E2 synthesis. The study concluded that the 40 percent ethanol extract of mangosteen hull inhibits histamine release and prostaglandin E2 synthesis.
Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells.
Biochemical Pharmacology. 2002 January 1;63(1):73-9
The hulls of mangosteen fruits (Garcinia mangostana) are traditionally used in Southeast Asia for the treatment of skin infection, allergy, wounds and diarrhea. The aim of this study was to determine the effect of one specific phytochemicals on mangosteen peel, the xanthone gamma-mangostin, on the arachidonic acid cascade in rat glioma cells. The researchers found that gamma-mangostin had a potent dose-dependent inhibitory activity on prostaglandin E2 release. Gamma-mangostin inhibited the conversion of arachidonic acid to prostaglandin E2 in microsomal preparations, showing its possible inhibition of the activity of cyclooxygenases. This is the first study to show gamma-mangostin directly inhibits the activity of cyclooxygenases. Inhibition of cyclooxygenases can provide relief from the symptoms of inflammation and pain.
Antioxidative and neuroprotective activities of extracts from the fruit hull of mangosteen (Garcinia mangostana Linn.).
Medical Principles and Practice. 2006;15(4):281-7
The objective of this study was to investigate the antioxidative and neuroprotective activities of extracts of hull of mangosteen fruits (Garcinia mangostana). Different solvents were used to make the extracts. All types of mangosteen extracts showed antioxidant activity. The mangosteen extract with the highest free radical scavenging activity were tested for their neuroprotective on neuroblastoma cells, which were treated with hydrogen peroxide. The researchers found that both tested extracts showed neuroprotective activity. They concluded that extracts from the hulls of mangosteen may be potent neuroprotectants.