The effect of tyrosol, hydroxytyrosol and oleuropein on the non-enzymatic lipid peroxidation of rat liver microsomes.
Molecular and Cellular Biochemistry. 2001 January;217(1-2):35-41
Hydroytyrosol could help to reduce the risk of heart disease. The aim of this in vitro study was to investigate the effects of tyrosol, hydroxytyrosol and oleuropein on the non-enzymatic lipid peroxidation, induced by ascorbate-Fe2+, in rat liver microsomes. The effect on lipid peroxidation was measured with chemiluminescence (emission of light). They found that hydroxytyrosol showed strong inhibition of lipid peroxidation, which was 6 times stronger than oleuropein. Tyrosol showed no inhibition of lipid peroxidation. However tyrosol, but not hydroxytyrosol, was able to change the fatty acid composition. The study concluded that hydroxytyrosol showed the highest protection again lipid peroxidation and that oleuropein only protected at higher concentrations.
Formation of F2-isoprostanes in oxidized low density lipoprotein: inhibitory effect of hydroxytyrosol.
Pharmacological Research. 1995 May;31(5):275-9
Oxidative damage of low-density lipoproteins increases the risk for atherosclerosis and heart disease. Isoprostanes are markers of lipid peroxidation and are produced from arachidonic acid after free radical injury and have strong biological activities. Natural antioxidants found in olive oil, fruits and vegetables may reduce the risk of oxidative damage and may protect against atherosclerosis. This in vitro study demonstrated that the formation of isoprostanes was inhibited by a hydroxytyrosol rich olive oil extract. Administration of hydroxystyrosol may help to reduce the risk of heart disease.
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