| |
|
|
|
|
Cancer and Hydroxystyrosol |
|
|
Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis.
European Journal of Cancer Prevention. 2002 August;11(4):351-8
Epidemiologic studies and animal studies show that olive oil may reduce the risk of several diseases such as cancer and heart disease. The aim of this study was to determine the effect of the main polyphenol in virgin olive oil, hydroxytyrosol, on tumor growth. The in vitro test were carried out in human colon cancer and leukemia cell lines. They found that hydroxytyrosol inhibited proliferation of both cancer cell lines. human promyelocytic leukaemia cells HL60 and colon adenocarcinoma cells HT29 and HT29 clone 19A. Hydroxytyrosol induced cell apoptosis and reduced cancer cell proliferation was reduced up to 50 percent. Hydroxytyrosol caused no such effects on non-cancer human cells, such as lymphocytes and polymorphonuclear cells. The study concluded that hydroxytyrosol may protect against cancer by arresting cell cycle and inducing apoptosis in cancer cells.
Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis.
Biochemical and Biophysical Research Communications. 2000 November 30;278(3):733-9
Hydroxytyrosol is a natural phenolic antioxidant found in olive oil. It has many claimed biological and pharmacological activities. The aim of this study was to investigate the effect of hydroxytyrosol on the proliferation and survival of a leukemia cell line. The researchers found that hydroxytyrosol caused a complete arrest of leukemia cell proliferation and even induced apoptosis. This apoptotic effect was not observed with tyrosol, suggesting that presence of two ortho-hydroxyl groups is required. The study concluded that hydroxytyrosol reduces the immunological response, resulting in antinflammatory and chemopreventive effects.
|
If you like this page, please click on the +1 button at the top right. Thanks a lot!
|
|
