One-month administration of hydroxytyrosol, a phenolic antioxidant present in olive oil, to hyperlipemic rabbits improves blood lipid profile, antioxidant status and reduces atherosclerosis development.
Atherosclerosis. 2005 Nov 17
The aim of this study was to determine the antioxidant property of hydroxytyrososl and its effects on blood lipids, on the progression of aortic lesions in hyperlipemic rabbits. The rabbits were divided in 8 groups with different diets, some including four milligram hydroxytyrosol per kg body weight. The researchers found that the addition of hydroxytyrosol to a diet high in saturated fat and cholesterol considerably reduced total cholesterol and increased HDL cholesterol. The supplementation with hydroxytyrosol improved the antioxidant status and reduced the size of atherosclerotic lesions. The study concluded that hydroxytyrosol may have cardioprotective effects.
A thromboxane effect of a hydroxytyrosol-rich olive oil wastewater extract in patients with uncomplicated type 1 diabetes.
European Journal of Clinical Nutrition. 2005 May;59(5):727-30
The aim of this study was to determine the antioxidant effect of an extract obtained from wastewater of an olive mill. The extract contained high levels of hydroxytyrosol and was administered to type 1 diabetes patients with their breakfast. Analysis of the blood and urine showed that hydroxytyrosol mainly reduced platelet aggregation but had no influence on total cholesterol, HDL-cholesterol and triglycerides. The plasma levels of the vitamins A, E and beta-carotene were not influenced by hydroxytyrosol. The study concluded that hydroxytyrosol causes antiaggregating platelet action and could help to reduce the risk of thromboses.
Antioxidant effect of hydroxytyrosol (DPE) and Mn2+ in liver of cadmium-intoxicated rats.
Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology. 2002 December;133(4):625-32
Intoxication of rats with cadmium results in the formation of thiobarbituric acid reactive substances (TARS). Administration of manganese or hydroxytyrosol resulted in a reduced production of TARS, which is the result of their antioxidant action. In vitro tests with rat liver microsomes also showed antioxidant activity of hydroxytyrosol and manganese. The study concluded that both hydroxytyrosol and manganese may have an antioxidant effect in the livers of cadmium-intoxicated rats.
Olive phenol hydroxytyrosol prevents passive smoking-induced oxidative stress.
Circulation. 2000 October 31;102(18):2169-71
Epidemiological studies have shown that the intake of antioxidants results in a reduced risk for several degenerative disorders such as cancer and atherosclerosis. Olive mill waste water is a byproduct of olive oil production and is phenols, such as hydroxytyrosol. The aim of this study was to investigate the effect of a low dose of olive mill waste extract on rats, which were exposed to smoke-induced oxidative stress. The oxidative damage was quantified by measuring the level of 8-iso-prostaglandin-F-2alpha (indicator of lipid peroxidation) in the urine. Passive smoking considerably increased oxidative damage. Treatment with the olive mill waste water resulted in considerably less oxidative damage. The study concluded that a low dose of hydroxytyrosol, administered through olive mill waste water, reduces the oxidative stress of rat exposed to passive smoking.
Hydroxytyrosol, as a component of olive mill waste water, is dose- dependently absorbed and increases the antioxidant capacity of rat plasma.
Free Radical Research. 2001 March;34(3):301-5
Hydroxytyrosol is a main antioxidant found in olive oil and olive mill waste water. The bioavailability of hydroxytyrosol is still unclear. The aim of this in vivo study was to investigate the absorption of polyphenols from olive mill waste water in rats. The mice were fed with extracts from olive mill waste water extract and urine was collected and analyzed after for 24 hours. They found that hydroxytyrosol was dose-dependently absorbed and excreted in the urine. Administration of this olive mill waste water extract also resulted in increased plasma antioxidant capacity.
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