Protective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver.
Food and Chemical Toxicology. 2006 June;44(6):862-7
Guarana is rich in tannins which may have protective effects against DNA damage. The aim of this study was to investigate the anti-cancer property by investigating the protective effects of guarana on mice injected with the carcinogen N-nitrosodiethylamine. The protective effect was evaluated with the comet assay (sensitive technique for the detection of DNA damage at the level of the individual cell) and DNA smear fragmentation technique. They found that the guarana pretreatment reduced the comet tale length, indicating a lower level of damage. The DNA smear fragmentation technique also confirmed that guarana has a protective effect. They concluded that guarana protects against DNA damage in mouse liver induced by the carcinogen N-nitrosodiethylamine.
Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guaranį, on mouse hepatocarcinogenesis.
Cancer Letters 2006 February 20;233(1):158-64
This in vivo study investigated the protective effect of guarana on mouse hepatocarcinogenesis. The mice were treated with the carcinogen N-nitrosodiethylamine and different doses of guarana. The researchers found that the numbers of macroscopic lesions were reduced. The highest dose of guarana resulted in reduction of preneoplastic lesions and a lower expression of cell nuclear antigen. They concluded that guarana showed an hepatocarcinogenesis in mice.
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