Defatted milled grape seed protects adriamycin-treated hepatocytes against oxidative damage.
European Journal of Nutrition. 2006 August;45(5):251-8
Defatted milled grape seed is a by-product from the wine industry and contain high levels of phytochemicals. This study investigates the protective effects of defatted milled grape seed on rat liver cells, after exposure to the drug adriamycin. The oxidative stress was determined from levels of thiobarbituric acid reactant substances and carbonyl compounds. The researchers found that the defatted milled grape seed protects the cells against oxidative damage by reducing damage to membranes and reducing oxidation of proteins and lipids. The study concluded that defatted milled grape seed may be used to reduce oxidative stress.
Protective effects of grape suspension on in vivo ischaemia/reperfusion of the rabbit bladder.
BJU International. 2005 Dec;96(9):1397-402
Reperfusion injury is damage to tissue caused when blood supply returns to the tissue after a period of absence of blood and oxygen (ischemia). The absence of oxygen and nutrients in tissue creates a condition where the tissue may become damage by oxidation or inflammation. The aim of this in-vivo study was to investigate the potential protective effect of a grape suspension on bladder dysfunction of rabbits exposed to reperfusion. Feeding of the grape suspension caused a significant reductions in the contractile responses. Examination of the bladder tissue showed less hypoxia (shortage of oxygen) in rabbits fed with the grape suspension. The study concluded that feeding rabbits with grape suspension protect against the oxidative damage of reperfusion after ischaemia.
Effects of different grape formulations on antioxidative capacity, lipid peroxidation and oxidative DNA damage in aged rats.
Journal of Nutritional Science and Vitaminology.2006 Feb;52(1):33-46
The aim of this study was to determine the antioxidant and anti-mutagenic capacity of different products (whole grapes, juice and pomace) from Campbell Early grapes. The in-vivo study was carried out on 120 male rats. The diet of the rats was supplemented with dry powder of the grape products. The grape pomace contained the highest levels of flavonoids and vitamins A and E. The level of vitamin C was the same for the three grape products. Intake of the grape products resulted in lower plasma and liver levels of thiobarbituric acid reactive substances (indicator of lipid peroxidation). Intake of grape products also resulted in increased levels of antioxidant enzymes. The study concluded that the intake of grape products, especially grape pomace, significantly inhibited lipid oxidation related to age or induced by cadmium. The grape product reduced oxidative damage of DNA and increased antioxidant enzyme activities of liver and red blood cells.
Defatted milled grape seed protects adriamycin-treated hepatocytes against oxidative damage.
European Journal of Nutrition. 2006 August;45(5):251-8
Defatted milled grape seed is a by-product from the wine industry and contain high levels of phytochemicals. This study investigates the protective effects of defatted milled grape seed on rat liver cells, after exposure to the drug adriamycin. The oxidative stress was determined from levels of thiobarbituric acid reactant substances and carbonyl compounds. The researchers found that the defatted milled grape seed protects the cells against oxidative damage by reducing damage to membranes and reducing oxidation proteins and lipids. The study concluded that defatted milled grape seed may be used to reduce oxidative stress.
|
