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Abstracts about genistein. |
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Effect of pure genistein on bone markers and hot flushes
Climacteric. December 2005, 8(4):371-9
The objective of this study was to determine the effect of the daily intake of 90 mg of genistein on markers of bone turnover and menopausal symptoms. About 100 women participated in the study. The genistein was purified according to the British Pharmacopoeia standards. In women with significant hot flushes, genistein reduced menopausal symptoms by 30 percent. Intake of genistein showed no statistically significant effect on the markers of bone turnover, possibly due to the short period of the test. The study concluded that a daily intake of 90 mg pure genistein reduces the number of hot flushes in postmenopausal women but the effect is mild.
Effect of pure genistein on bone markers and hot flushes
Climacteric. December 2005, 8(4):371-9
The objective of this study was to determine the effect of the daily intake of 90 mg of genistein on markers of bone turnover and menopausal symptoms. About 100 women participated in the study. The genistein was purified according to the British Pharmacopoeia standards. In women with significant hot flushes, genistein reduced menopausal symptoms by 30 percent. Intake of genistein showed no statistically significant effect on the markers of bone turnover, possibly due to the short period of the test. The study concluded that a daily intake of 90 mg pure genistein reduces the number of hot flushes in postmenopausal women but the effect is mild.
Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L-carnitine
European Journal of Nutrition, 2005 December
The soy isoflavone genistein increases the activity of the enzyme Carnitine palmitoyltransferase (CPT1A), which is a rate-limiting enzyme in the the mitochondrial beta-oxidation pathway, and suppresses high fat induced obesity in mice. The aim of this study was to see if genistein or daidzein stimulated the activity of L-carnithin. The activity of L-carnithin was assessed by measuring mRNA expression levels of CPT1A. Shin and his colleagues found that the enzyme activity of CPT1A was at least 2.3 fold higher when L-carnithin and genistein were combined. Daidzein also significantly increased the mRNA expression of CPT1A.
Genetic toxicity studies with genistein.
Food Chemistry Toxicology, 2006 January, 44(1):42-55
Epidemiological studies have shown that populations who more phytoestrogens such as genistein have lower cancer and other diseases. Although soy has been consumed at high levels in Asian populations without apparent adverse effects there some concern about of potential adverse effects of soy isoflavones. For this study, the mutagenicity and clastogenicity of genistein measured with the Ames test, the mouse lymphoma test and in vivo in the micronucleus test in mice and rats. With the Ames test, no mutagenic effects were observed. In the in vitro test showed that genistein increased resistant mutants. The in vivo test showed no increase in micronuclei in treated mice or rats treated with genistein.
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