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Cranberry and the Urinary Tract

Cranberry juice and bacterial colonization in children--a placebo-controlled randomized trial.
Journal of Clinical Nutrition. 2005 December;24(6):1065-72.
In-vitro studies have shown that cranberry prevents the growth and adhesion of many bacteria and that cranberry juice prevents urinary tract infections. Most studies have investigated the effects of cranberry on women. The aim of this study is to investigate the effect of cranberry in children. More specifically the researchers were looking for the influence on nasopharyngeal and colonic bacterial flora, the acceptance of cranberry juice and influence on infectious diseases. The researchers found that cranberry juice was well accepted by the children but that it no effect on bacterial composition of the nasopharynx. They concluded that cranberry juice has only beneficial effect on urinary tract.

Use of cranberry in chronic urinary tract infections.
M?decine et maladies infectieuses. 2006 July 17
Chronic cystitis in women is usually treated with antibiotics. The purpose of this study was to make a review of scientific literature about the use of cranberry to treat cystitis. They found that the phytochemical proanthocyanidin could reduce the adhesion of Escherichia coli adhesion to the liners of the urinary tract and that intake of cranberries reduces the incidence of acute cystitis. However prescriptions modalities are still not well defined.

Cranberry for Prevention of Urinary Tract Infections
American Family Physician 2004;70:2175-77
Cranberry has traditionally been used to prevent and treat urinary tract infections. Studies have shown that the action of cranberry is by preventing the attachment of bacteria to membranes. Only recently research has shown that cranberry can be used to prevent urinary tract infections. There are no clinical studies indicating that cranberry has other clinical uses. On the other hand, cranberry is a safe product without significant interaction with drugs.

What's the use of cranberry juice?
Age Ageing. 2000 January;29(1):9-12
About one quarter of women, especially older women, will experience a urinary tract infection. Use of antibiotics is not always effective and can lead to side effects such as Candida infection or diarrhoea. The purpose of this study was to investigate the literature about the efficacy of cranberry juice as a therapy. Most research has been done on the prevention and treatment of urinary tract infections. Cranberry juice is more effective in preventing bacteria, such as Escherichia coli, for adhering to epithelial cells than removing bacteria already attached to cell membranes. Many studies, many of which are uncontrolled or anecdotal, show a favourable effect of cranberry juice on urinary tract infections. In vitro studies have suggested other health benefits: anti-carcinogenic, fungistatic, inhibition of low density lipoprotein oxidation and prevention of formation of dental plaques. The use of cranberry juice has the following problems: development of bacterial resistance is unknown, optimal dose is still unknown, high oxalate content and its high cost.

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