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Cranberry and Stomach Ulcers |
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Inhibition of Helicobacter pylori and associated urease by oregano and cranberry phytochemical synergies.
Applied and Environmental Microbiology. 2005 December;71(12):8558-64
Helicobacter pylori is an important cause for the development of stomach ulcers. Because treatment with antibiotics is not always effective to eliminate Helicobacter pylori treatment with phytochemicals from plant or vegetables could be interesting. The aim of this in-vitro study was to investigate the antimicrobial effect of phenolic phytochemicals from cranberry and oregano on Helicobacter pylori. Different mixtures of phytochemicals from cranberry and oregano were tested. The objective of this study was to determine the potential for using phenolic phytochemical extracts to inhibit H. pylori in a laboratory medium. The researchers found that the antimicrobial effects of mixtures were greater in extract mixtures than in individual extracts, meaning that oregano and cranberry phytochemicals work synergistically.
Efficacy of cranberry juice on Helicobacter pylori infection: a double-blind, randomized placebo-controlled trial.
Helicobacter. 2005 April;10(2):139-45
Helicobacter pylori infection is a major cause of stomach ulcers and gastric cancer. The aim of this study was to investigate the effect of cranberry juice consumption on the suppression of Helicobacter pylori. After a period of 35 and 90 days the level of Helicobacter pylori infection was determined with the 13C-urea breath test. Helicobacter pylori produces the enzyme urease which produces carbon dioxide. Patients are given urea with 13C carbon. The released carbon dioxide is analyzed for 13C carbon. The researchers found that after 90 days patients who consumed cranberry juice yielded more than twice as much negative results. The study concluded that regular consumption of cranberry juice can suppress Helicobacter pylori infection in endemically afflicted populations and may reduce the risk of stomach ulcers.
Susceptibility of Helicobacter pylori isolates to the antiadhesion activity of a high-molecular-weight constituent of cranberry.
Diagnostic Microbiology and Infectious Disease. 2004 December;50(4):231-5
Helicobacter pylori is a main cause of stomach ulcers, but many Helicobacter pylori strains are resistant to treatment with antibiotics. The aim of this study was to investigate the antiadhesion properties of high molecular weight cranberry extracts on the antiadhesion effect of 83 Helicobacter pylori isolates. About two thirds of the isolates were inhibited by the cranberry extract. The researchers concluded that a combination of cranberry extract and the antibiotic metronidazole may improve the eradication of Helicobacter pylori.
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