Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2'-deoxyguanosine levels in the Fischer 344 rat.
Nutrition and Cancer. 2001;40(2):125-33
This in vivo study examined the effects of lyophilized black raspberries on azoxymethane induced aberrant crypt foci, colon tumors, and urinary 8-hydroxy-2'-deoxyguanosine levels. The rats were injected with the carcinogen azoxymethane and were put on diets containing different levels of lyophilized black raspberries. The researchers found that the intake of lyophilized black raspberries caused a significant reduction of aberrant crypt foci and tumor multiplicity. They concluded that lyophilized black raspberries inhibit several measures of azoxymethane induced colon carcinogenesis and modulate a marker of oxidative stress.
Black raspberry extract and fractions contain angiogenesis inhibitors.
Journal of Agricultural and Food Chemistry. 2005 May 18;53(10):3909-15
Inhibition of angiogenesis will result in reduced tumor growth. The aim of this in vitro study was to investigate the anti-angiogenic property of black raspberry extract. The extract was able to completely inhibited angiogenesis and tumor vessel growth. One of the phytochemicals responsible for this action was gallic acid. The researchers concluded that black Raspberry extracts may be used as complementary cancer therapy.
Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells.
Journal of Medicinal Food. 2001 Spring;4(1):49-51
The aim of this study was to investigate the anti-carcinogenic activity of extracts form different cultivars of raspberries and blueberries. The activity was tested on cervical and breast cancer cell lines. Ethanol extracts from all tested fruits strongly inhibited the cervical and breast cancer cell lines. Aqueous extract of the raspberries raspberry and the ethanol extract of Premier blueberry significantly inhibited mutagenesis initiated by carcinogens.
Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor kappa-B by black raspberry extracts.
Cancer Resarch. 2002 December 1;62(23):6857-63
Previous studies with rodents have shown that black raspberry inhibit the development of esophageal and colon cancer, induced by carcinogens. An in-vitro test has also illustrated that organic extracts from black raspberry inhibit the induced cell transformation. The exact molecular mechanism of this protective action was still unclear and was the subject of this in-vitro study. Mouse epidermal cells were exposed to the carcinogen benzo(a)pyrene diol-epoxide and treated with several organic blackberry extracts. The researchers found that pre-treatment with several extracts resulted in the inhibition of activated protein-1 and nuclear factor kappa-B. The study concluded that the anti-tumor activity of black berry extracts are probably caused by their mediation of pathways resulting in reduced activation of activated protein-1 and nuclear factor kappa-B.
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